HPA-4的不相容性可能导致实体器官移植的排斥反应
发布时间：2010年09月12日
来源：南宁输血医学研究所血小板免疫学网 阅读次数：
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作者：Tsuno NH, Kawabata M, Matsuhashi M等来源：Vox Sanguinis, 2010 july, Supplement1,Vol 99 背景：人类血小板抗原（HPA）系统与新生儿同种免疫血小板减少（NAIT）、输血后紫癜（PTP）以及血小板输注无效（PTR）有着密切的联系。HPA抗原系统的等位基因频率在不同的人群中有所差异，HPA抗原的不相容导致同种抗体的产生，成为形成上述情况的原因。最近，HPA的多态性涉及到血栓的形成条件，例如缺血性中风。另外，HPA的不相容性与肾脏预后差以及骨髓移植有关，表明HPA同种抗原在移植中起到次要的组织相容性抗原的作用。 HPA-4 INCOMPATIBILITY MAY CAUSE REJECTION REACTIONS IN SOLID ORGAN TRANSPLANTATION Tsuno NH, Kawabata M, Matsuhashi M, Hasegawa K, Tamura S, Kaneko J, Aoki T, Takemura N, Sugawara Y., Kokudo N., Takahashi K.Vox Sanguinis, 2010 july, Supplement1,Vol 99 Background: Human platelet antigen (HPA) systems have been implicated in neonatal alloimmune thrombocytopenia (NAIT), post-transfusion purpura (PTP) and platelet transfusion refractoriness (PTR). The allelic frequency of the HPA antigen system varies among the various populations, and their incompatibility results in the production of alloantibodies, which are responsible for the above conditions. More recently, HPA polymorphism has been implicated in thrombotic conditions, such as ischemic stroke. In addition, HPA incompatibility has been associated with poor prognosis in kidney as well as bone marrow transplantation, suggestive that HPA alloantigens may act as minor histocompatibility antigens in transplantation. |
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